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M94A3192.TXT
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1994-10-25
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Document 3192
DOCN M94A3192
TI Involvement of B cell subpopulation in progression of murine
retrovirus-induced immunodeficiency syndrome.
DT 9412
AU Hitoshi Y; Numata F; Uehara S; Takatsu K; Dept. Immunol., Univ. Tokyo,
Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):132 (abstract no. PA0147). Unique
Identifier : AIDSLINE ICA10/94369383
AB OBJECTIVE, Infection of susceptible C57BL/6 (B6) mice with LP-BM5 MuLV
leads to the development of the murine acquired immunodeficiency
syndrome (MAIDS), which shows many similarities with human AIDS. It has
been reported that B cells are required for the progression of MAIDS. In
our previous study, X chromosome-linked immunodeficiency mice (XID),
which lack functionally mature B cells, show delayed progression of
MAIDS. However it is not clear what is the cellular mechanisms of
impaired progression of MAIDS in XID mice. Here we report that XID mice
developed MAIDS after transplantation of B cells from infected B6 mice.
METHODS, We transplanted spleen cells, lymphnode cells or purified B and
T cells from LP-BM5 MuLV-infected B6 mice into XID mice and analyzed the
development of MAIDS-related symptoms such as lymphadenopathy,
hypergamma-globulinemia and low responsiveness to LPS or ConA. RESULTS,
MAIDS-related symptoms were observed in XID mice within 10 weeks after
the transplantation. However, XID mice did not show any symptoms of
MAIDS till at least 20 weeks after LP-BM5 MuLV injection. Expansion of B
cells and CD4+Thy1- cells in lymphnodes, which is one of the
characteristics of MAIDS, was observed in the transplanted XID mice.
Then we transplanted purified T or B cells from virus-infected B6 mice
to XID mice. The B cells induced MAIDS-related symptoms in XID mice more
severely than unfractionated cells. In contrast, the T cells did not
induce MAIDS in XID mice. DISCUSSION AND CONCLUSION, We conclude that B
cells from virus-infected B6 mice play an important role in triggering
the progression of MAIDS in XID mice. Now we are trying to define what
kind of B cell subpopulation is required for triggering the disease.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY Animal B-Lymphocyte
Subsets/*IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY Comparative Study Human
Immunologic Deficiency Syndromes/GENETICS/IMMUNOLOGY *Leukemia Viruses,
Murine Lymph Nodes/IMMUNOLOGY *Lymphocyte Transfusion Mice Mice,
Inbred C57BL Mice, Mutant Strains Murine Acquired Immunodeficiency
Syndrome/*IMMUNOLOGY Spleen/IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY Time
Factors X Chromosome MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).